Metals Bhasma are used in Ayurveda and another Indian system of medicine, but their use is also described in the Chinese and Egyptian civilizations dating back to 2500 BC. Bhasma is a unique Ayurvedic metal/mineral preparation, treated with herbal juices or decoctions and exposed to Ayurveda, known from the 7th century AD in the Indian subcontinent and used to treat a variety of chronic diseases. is widely recommended for Animal derivatives such as horns, shells, feathers, Dhatus, non-Dhatu, and herbs are commonly given in the form of Bhasma. Bhasma means ash obtained from incineration; The starter material goes through an elaborate process of purification and this process is followed by a reaction phase, which involves the addition of some other minerals and/or herbal extracts. Bhasma has various significance such as maintaining optimum alkalinity for optimum health, and neutralizing harmful acids that cause disease; Because Bhasma is not metabolized, they do not produce any harmful metabolites, rather it breaks down heavy metals in the body. Methods of preparation of incense are Parapati, Rasyoga, Sindora, etc. Bhasma containing Fe, Cu, S or other manufacturing processes plays a specific role in the final product(s). The particle size (1-2 µm) is significantly reduced, which may facilitate the absorption and assimilation of the drug into the body system. Standardization of incineration is essential to confirm its identity and determine product quality, purity, safety, effectiveness, and acceptability. But the most important challenges facing these formulations are the lack of complete standardization by Physico-chemical standards.

Keywords: Ayurveda, Bhasma, Marna, nano-particle, purification, standardization